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| Neither biases in patients' randomization or in blood pressure control during the rein study accounted for the different outcome predicted by the two models for patients on ramipril as compared with controls. | like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. Pine bark extract (pycnogel) may help improve blood flow to muscles and reduce leg cramps, according to a small 2006 study of patients with intermittent claudication. | Significantly fewer patients on ramipril had cognitive or functional impairment. |
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